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KMID : 0438219760130010089
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Korea University Medical Journal
1976 Volume.13 No. 1 p.89 ~ p.95
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Changes of Fetal Development in Pregnant Rats Exposed to Carbon monoxide
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Abstract
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Although carbon monoxide poisoning of pregnant woman was reported in 1859, very little has written about the effect of carbon monoxide on the fetus in uterus.
Furthermore in this country, the major heat sources in private houses are coal products and this matter has given special emphasis on the pregnant women spending most of their lives in kitchens in which the air is easily and frequently polluted with carbon monoxide.
With the reasons, the primary trial to prove the pathogenesis of fetal carbon monoxide poisoning was carried out using 38 pregnant rats of Sprague-Dawley species with 37 fetuses. As for the methodology, the rats were devided into two groups of control and exposure group.
The latter was exposed to 500pp . of carbon monoxide through Douglas bag for 4 hours per day for 20 days continuously. And then, the fetuses were examined.
The results of the experiment were as follows;
1. The abortion rate of exposure group was 44.6% by average showing significant relative risk of 3.3 comparing with 13.4% of the rate of control group. (P<0.005)
2. The fetuses of the exposure group were significantly lighter than those of control group showing diff erence of 0.57 gm by average, that is, 3.910.08 gm of exposure group and 4.480.14 gm of control group. ( P <0.001)
3. The brains of fetuses of exposure group were significantly ligher than ones of control group showing difference of 17.6 mg by average. ( P <0.05)
4. The fetuses of the exposure group are shorter in length by 0.13cm by average, however, the difference is not significant statistically. (P<0.1)
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